Even the most playful pups can face stiff joints and achy limbs as they grow, no matter their age or breed. Just like humans, dogs can benefit from a little extra support to keep them moving comfortably and joyfully.
That’s why we at Nexus Pets have rounded up the 10 best vet-approved joint supplements for dogs with arthritis carefully selected to help your furry friend stay active, happy, and pain-free.
1. Glucosamine & Chondroitin
Glucosamine and chondroitin are foundational nutrients for canine joint health, forming the primary structural components of cartilage. These compounds work synergistically to support cartilage repair, maintain joint integrity, and protect against progressive wear and tear. Dogs suffering from arthritis or age-related joint degeneration often benefit significantly from supplementation, as it helps reduce inflammation within the joints, alleviating discomfort during movement.

By promoting flexibility and cushioning of the joints, glucosamine and chondroitin allow dogs, particularly senior or large-breed canines, to regain and maintain mobility. These supplements are widely available in multiple forms, including chewable tablets, soft chews, and liquids, providing convenient options to suit a variety of canine preferences. Veterinarians frequently recommend these ingredients as a core element of any comprehensive arthritis management plan.
2. Omega-3 Fatty Acids (Fish Oil)
Omega-3 fatty acids, commonly sourced from high-quality fish oil, offer potent anti-inflammatory properties that are especially beneficial for dogs experiencing joint pain or stiffness. By reducing inflammation in affected areas, omega-3s help slow cartilage degradation while supporting overall joint function and comfort.

In addition to joint benefits, these fatty acids contribute to healthier skin and a glossy coat, enhancing your dog’s overall well-being. Available in liquid or capsule form, omega-3 supplements can be easily integrated into a dog’s daily regimen, either mixed with meals or administered directly. Many veterinarians advocate their use for dogs of all ages, particularly those with arthritis or breeds predisposed to joint issues, as they provide both therapeutic and preventive support.
3. Hyaluronic Acid
Hyaluronic acid is a naturally occurring substance in the synovial fluid that cushions and lubricates joints, reducing friction and preventing further cartilage damage. Supplementing with hyaluronic acid can significantly ease stiffness and discomfort, allowing dogs to move more freely and with less pain.

Beyond lubrication, it also supports cartilage protection and enhances overall joint flexibility, which is critical for dogs recovering from arthritis or other degenerative joint conditions. This supplement is versatile, found in tablets, liquids, fortified treats, and even bone broths, making it simple to incorporate into a dog’s daily routine. Veterinary professionals recognize hyaluronic acid as a valuable adjunct to other joint support strategies, especially for senior dogs or those with advanced arthritis.
4. MSM (Methylsulfonylmethane)
MSM, or methylsulfonylmethane, is an organic sulfur compound known for its role in supporting connective tissue health and reducing inflammation. Regular supplementation with MSM can help decrease joint swelling and pain while promoting the repair of cartilage, ligaments, and tendons.

By reinforcing the structural components of joints, MSM contributes to improved mobility, flexibility, and overall comfort, particularly in dogs with chronic arthritis or active dogs prone to joint strain. Available in tablets, powders, and liquids, MSM can be administered alone or combined with other joint-supporting nutrients such as glucosamine and chondroitin for a synergistic effect. Many veterinarians recommend MSM as a complementary therapy to help maintain long-term joint function.
5. Turmeric (Curcumin)
Turmeric, specifically its active compound curcumin, offers powerful natural anti-inflammatory and antioxidant effects, making it increasingly popular as a joint-support supplement for dogs. Curcumin works by reducing joint pain and swelling, improving overall mobility, and protecting tissues from oxidative stress that can accelerate joint degeneration.

Dogs with arthritis or other inflammatory joint conditions may experience notable improvements in comfort and activity levels when turmeric is incorporated into their diet. Available in capsules, powders, or as a food additive, turmeric provides a versatile and natural approach to supporting joint health. Many holistic veterinarians now recommend curcumin as part of a comprehensive joint care regimen, particularly when combined with other joint-support supplements.
6. Vitamin C
Vitamin C is a powerful antioxidant that plays a critical role in maintaining healthy joints in dogs by combating oxidative stress, which can accelerate cartilage breakdown. Beyond its antioxidant activity, vitamin C is essential for collagen synthesis, the protein responsible for providing structure and resilience to cartilage, tendons, and ligaments. By promoting collagen production, vitamin C strengthens connective tissues and supports long-term joint integrity, helping dogs move with greater ease and comfort.

Additionally, it contributes to overall immune function, supporting a dog’s ability to fend off infections and recover from minor injuries. Available in tablets, chewables, powders, or fortified foods, vitamin C supplements can be integrated into a dog’s daily diet, particularly for senior dogs or those prone to arthritis. While not universally prescribed, many veterinarians recommend it as part of a broader joint-support regimen to complement other supplements.
7. Devil’s Claw
Devil’s Claw, a traditional herbal remedy, is increasingly recognized for its natural analgesic and anti-inflammatory properties, making it a popular alternative for managing joint discomfort in dogs. The active compounds in Devil’s Claw, primarily harpagosides, interact with inflammatory pathways to reduce pain and stiffness in affected joints. Dogs with arthritis or mild musculoskeletal issues may experience enhanced mobility and improved activity levels when Devil’s Claw is incorporated into their care routine.

Its natural composition allows it to be used as a complementary option to conventional NSAIDs, providing relief without the same risk of side effects. Available in capsules, powders, and liquid extracts, this herb is gaining traction in holistic veterinary practices and is especially suited for pet owners seeking plant-based approaches to joint care.
8. Boswellia Serrata
Boswellia Serrata, derived from Indian frankincense, is a potent herbal anti-inflammatory known for alleviating swelling and joint discomfort in dogs. The bioactive compounds, called boswellic acids, inhibit pro-inflammatory enzymes, providing rapid relief from pain and stiffness in arthritic or overused joints. Regular supplementation can enhance joint flexibility, improve range of motion, and help dogs maintain active lifestyles despite age-related degeneration or chronic arthritis.

Boswellia Serrata is available in capsules, powders, and liquid extracts, offering versatility in administration. Veterinary professionals increasingly recommend it as part of multimodal joint care, particularly for dogs whose owners prefer natural, plant-based alternatives to traditional medications. Its combination of fast-acting properties and long-term joint support makes it an attractive addition to canine arthritis management programs.
9. Green-Lipped Mussel (GLM)
Green-Lipped Mussel (GLM) is a marine superfood celebrated for its dense concentration of bioactive compounds including glucosamine, chondroitin, omega-3 fatty acids, and glycosaminoglycans. This potent combination supports cartilage repair, reduces inflammation, and alleviates joint pain, enhancing mobility in dogs of all ages, particularly those affected by arthritis or joint degeneration.

GLM is highly bioavailable, meaning dogs can efficiently absorb and utilize its nutrients for optimal joint support. In addition to its musculoskeletal benefits, GLM contributes to overall wellness by supporting heart, kidney, and liver function. Available in capsules, powders, and fortified treats, GLM is widely recommended by veterinarians as a natural and effective supplement to maintain flexibility and joint health, even for breeds predisposed to arthritis.
10. Collagen
Collagen is a structural protein essential for maintaining the strength and integrity of cartilage, tendons, ligaments, and bones, making it a cornerstone for joint health in dogs. Supplementing with collagen helps reinforce connective tissues, supports cartilage repair, and improves overall joint flexibility, which is particularly beneficial for dogs with arthritis or degenerative joint conditions.

Beyond musculoskeletal support, collagen provides systemic benefits, promoting healthy skin, coat, nails, and digestive function, contributing to a dog’s overall vitality. It is available in capsules, powders, and bone broths, making it easy to incorporate into a dog’s diet. Veterinarians increasingly endorse collagen supplementation as part of a comprehensive joint-support strategy, especially when combined with glucosamine, chondroitin, or green-lipped mussel for synergistic effects.

